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A total of 335 patients with early Parkinson's disease(PD)were enrolled in a multicenter,randomized,double-blind trial designed to assess the efficacy and safety of pramipexole.The majority of patients completed the study(pramipexole 83%,placebo 80%).In the assessment of adverse events, nausea,insomnia,constipation,somnolence,and visual hallucinations occurred more frequently in the pramipexole treatment group compared with placebo patients.No clinically significant changes were noted in blood pressure or pulse rate.Overall,these results indicate that pramipexole is safe and effective in the treatment of early PD. |
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